Cheng-Yu Wu is born in Taichung, Taiwan. He began his musical education at the NationalFirst Senior High School and studied with Li-Ming Chen. He went to National Taiwan University studied philosophy and in the meantime he studied with Anders Norell and Yi-Hui Lin. Cheng-Yu Wu was the principal flute of The Ministry of National Defence Symphony Orchestra from 2003 till 2004. After the military service Cheng-Yu Wu went to Europe and studied with Harrie Starreveld, Marten Root, Marieke Schneemann, and Ellen Vergunst at Conservatorium van Amsterdam and participated in masterclass of Peter-Lukas Graf, András Adorján, Emily Beynon, and Kersten McCall. Cheng-Yu Wu got his master diploma of music from Conservatorium van Amsterdam in 2011.

Cheng-Yu Wu is well known as a flutist who is capable of various styles of music. He studied contemporary music with Harrie Starreveld and baroque flute with Marten Root. He formed his chamber music group, The CVA Trio, with violist Victor Gil Gazapo and harpist Anna Steinkogler in 2009; they were invited for concerts in the Netherlands and Austria. The Goudsbloemduo with pianist Harimada Kusuma was formed in 2008, until now they have performed concerts in the Netherlands, Belgium, Italy and Taiwan.
Since 2012, Cheng-Yu Wu started an experimental solo flute recital project "Just Flute?!". The project is very successful and soon he got invited to the Van Gogh Museum in Amsterdam, and Taipei International New Music Festival. Cheng-Yu Wu is well-known for his flexibility of performing different kinds of flutes for various styles of music. Beside concerts, Cheng-Yu Wu also gives lecture to flute or composition students. Cheng-Yu Wu is now active as a soloist and teacher in Amsterdam, Taiwan and Shanghai.